GABRE antibody (Middle Region)

Catalog No. ABIN2776248

Product Details anti-GABRE Antibody

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Binding Specificity: Middle Region

Reactivity: Human, Guinea Pig, Mouse, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KNSWKLFQFD FTGVSNKTEI ITTPVGDFMV MTIFFNVSRR FGYVAFQNYV

Predicted Reactivity: Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against GABRE. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GABRE

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 393 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-GABRE antibody (ABIN2776248)

Fatemi, Folsom, Rooney, Thuras: "Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder." in: Translational psychiatry, Vol. 3, pp. e303, (2013) (PubMed).

Hengen, Nelson, Stang, Johnson, Crader, Watters, Mitchell, Behan: "Increased GABA(A) receptor ?-subunit expression on ventral respiratory column neurons protects breathing during pregnancy." in: PLoS ONE, Vol. 7, Issue 1, pp. e30608, (2012) (PubMed).

Hengen, Gomez, Stang, Johnson, Behan: "Changes in ventral respiratory column GABAaR ?- and ?-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 300, Issue 2, pp. R272-83, (2011) (PubMed).

Target Details for GABRE

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Alternative Name: GABRE (GABRE Products)

Synonyms: GABRE antibody, gamma-aminobutyric acid type A receptor epsilon subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit epsilon antibody, GABRE antibody, Gabre antibody

Background: GABRE belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein Size: 393

Molecular Weight: 43 kDa

Gene ID: 2564

NCBI Accession: NM_021984, NP_068819

Pathways: Synaptic Membrane