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HSBP1 antibody (Heat Shock Factor Binding Protein 1) (N-Term) Primary Antibody

HSBP1 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN2776380
$389.00
Plus shipping costs $45.00
100 μL
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  • Target
    HSBP1
    Binding Specificity
    • 9
    • 4
    • 1
    • 1
    N-Term
    Reactivity
    • 32
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio)
    Host
    • 29
    • 2
    • 1
    Rabbit
    Clonality
    • 30
    • 2
    Polyclonal
    Conjugate
    • 11
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HSBP1 antibody is un-conjugated
    Application
    • 17
    • 16
    • 12
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    Western Blotting (WB)
    Sequence
    AETDPKTVQD LTSVVQTLLQ QMQDKFQTMS DQIIGRIDDM SSRIDDLEKN
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against HSBP1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human HSBP1
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 76 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tai, McFall, Huang, Demeler, Fox, Brubaker, Radhakrishnan, Morimoto: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, 2002 (PubMed).

  • Target
    HSBP1
    Alternative Name
    HSBP1 (HSBP1 Antibody Abstract)
    Synonyms
    HSBP1, npc-a-13, NPC-A-13, hsbp1, hsbp1a, 0610007A03Rik, AA408769, Hsp25, zgc:73224, heat shock factor binding protein 1 like 1, heat shock factor binding protein 1, Heat shock factor binding protein 1, heat shock factor binding protein 1 S homeolog, heat shock factor binding protein 1 L homeolog, heat shock factor binding protein 1b, HSBP1L1, HSBP1, Bm1_07370, hsbp1.S, hsbp1, hsbp1.L, Hsbp1, hsbp1b
    Background
    The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
    Alias Symbols: DKFZp686D1664, DKFZp686O24200, NPC-A-13
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-7, LNX1, KIAA1217, CCHCR1, CCDC53, SDCBP, KIFC3, HSBP1, UBC, VCP, RRBP1, RB1CC1, HSF1, HSPA1A, HSPA4,
    Protein Size: 76
    Molecular Weight
    8 kDa
    Gene ID
    3281
    NCBI Accession
    NM_001537, NP_001528
    UniProt
    O75506
    Pathways
    SARS-CoV-2 Protein Interactome
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