HSD11B2 antibody (N-Term)

Catalog No. ABIN405404

The Rabbit Polyclonal anti-HSD11B2 antibody is suitable to detect HSD11B2 in samples from Human, Rat, Mouse, Horse, Cow, Guinea Pig, Rabbit and Sheep. It has been validated for WB.

Quick Overview for HSD11B2 antibody (N-Term) (ABIN405404)

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Reactivity: Human, Rat, Mouse, Horse, Cow, Guinea Pig, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD11B2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HSD11B2 Antibody

Binding Specificity: N-Term

Sequence: ERWPWPSGGA WLLVAARALL QLLRSDLRLG RPLLAALALL AALDWLCQRL

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against HSD11B2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 44 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSD11B2

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Alternative Name: HSD11B2

Background: HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. It modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Alias Symbols: AME, AME1, HSD11K, HSD2, SDR9C3
Protein Interaction Partner: KAT2B, HDAC1, KAT2A, CTBP1,
Protein Size: 44

Molecular Weight: 45 kDa

Gene ID: 3291

NCBI Accession: NM_000196, NP_000187

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones