GPX3 antibody (N-Term)

Catalog No. ABIN2776848

This Rabbit Polyclonal antibody specifically detects GPX3 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Pig, Cow and Guinea Pig.It has been mentioned in 1 publication

Quick Overview for GPX3 antibody (N-Term) (ABIN2776848)

Target: GPX3 (Glutathione Peroxidase 3 (Plasma) (GPX3))

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPX3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GPX3 Antibody

Binding Specificity: N-Term

Purpose: GPX3 Antibody - N-terminal region

Sequence: DCHGGISGTI YEYGALTIDG EEYIPFKQYA GKYVLFVNVA SYUGLTGQYI

Predicted Reactivity: Cow: 100%, Dog: 83%, Guinea Pig: 79%, Human: 100%, Mouse: 100%, Pig: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GPX3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GPX3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101663

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-GPX3 antibody (ABIN2776848)

Maccarrone, Ditzen, Yassouridis, Rewerts, Uhr, Uhlen, Holsboer, Turck: "Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters." in: Journal of psychiatric research, Vol. 47, Issue 11, pp. 1572-80, (2013) (PubMed).

Target Details for GPX3

Target: GPX3 (Glutathione Peroxidase 3 (Plasma) (GPX3))

Alternative Name: GPX3

Background:

Background Information: GPX3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination.Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme. GPX3 expression appears to be tissue-specific.

Gene Name: Glutathione peroxidase 3 (plasma)

Alternative Symbols: GPx-P, GSHPx-3, GSHPx-P

Protein Name: Glutathione peroxidase 3

Molecular Weight: 26 kDa

Gene ID: 2878

NCBI Accession: NP_002075

UniProt: P22352

Pathways: Thyroid Hormone Synthesis