Hepcidin antibody (N-Term)

Catalog No. ABIN2776909

This Rabbit Polyclonal antibody specifically detects Hepcidin in WB. It exhibits reactivity toward Human and Rat.It has been mentioned in 1 publication

Quick Overview for Hepcidin antibody (N-Term) (ABIN2776909)

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hepcidin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Hepcidin Antibody

Binding Specificity: N-Term

Purpose: HAMP Antibody - N-terminal region

Sequence: MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM

Predicted Reactivity: Human: 100%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against HAMP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HAMP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41620-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Hepcidin antibody (ABIN2776909)

Theurl, Theurl, Seifert, Mair, Nairz, Rumpold, Zoller, Bellmann-Weiler, Niederegger, Talasz, Weiss: "Autocrine formation of hepcidin induces iron retention in human monocytes." in: Blood, Vol. 111, Issue 4, pp. 2392-9, (2008) (PubMed).

Target Details for Hepcidin

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Alternative Name: HAMP

Background:

Background Information: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature p

Gene Name: Hepcidin antimicrobial peptide

Alternative Symbols: HEPC, PLTR, HFE2B, LEAP1

Protein Name: Hepcidin

Molecular Weight: 9kDa

Gene ID: 57817

NCBI Accession: NP_066998

UniProt: P81172

Pathways: Hormone Activity, Transition Metal Ion Homeostasis