Hepcidin antibody (N-Term)

Catalog No. ABIN2776909

This Rabbit Polyclonal antibody specifically detects Hepcidin in WB. It exhibits reactivity toward Human and Ratand has been mentioned in 1 publication.

Quick Overview for Hepcidin antibody (N-Term) (ABIN2776909)

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hepcidin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Hepcidin Antibody

Binding Specificity: N-Term

Sequence: MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM

Predicted Reactivity: Human: 100%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against HAMP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HAMP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 84 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Hepcidin antibody (ABIN2776909)

Theurl, Theurl, Seifert, Mair, Nairz, Rumpold, Zoller, Bellmann-Weiler, Niederegger, Talasz, Weiss: "Autocrine formation of hepcidin induces iron retention in human monocytes." in: Blood, Vol. 111, Issue 4, pp. 2392-9, (2008) (PubMed).

Target Details for Hepcidin

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Alternative Name: HAMP

Background: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature p
Alias Symbols: HEPC, HFE2B, LEAP-1, LEAP1, PLTR
Protein Interaction Partner: CKAP4, VKORC1, SLC40A1,
Protein Size: 84

Molecular Weight: 9 kDa

Gene ID: 57817

NCBI Accession: NM_021175, NP_066998

UniProt: P81172

Pathways: Hormone Activity, Transition Metal Ion Homeostasis