HSD17B1 antibody (N-Term)

Catalog No. ABIN2776958

Product Details anti-HSD17B1 Antibody

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Pig, Cow, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 91%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HSD17B1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HSD17B1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 328 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-HSD17B1 antibody (ABIN2776958)

Tsuchiya, Nakao, Katoh, Sasaki, Hiroshima, Tanaka, Matsunaga, Hanaoka, Tsugane, Ikenoue: "Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19." in: Human reproduction (Oxford, England), Vol. 20, Issue 4, pp. 974-8, (2005) (PubMed).

Target Details for HSD17B1

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Alternative Name: HSD17B1 (HSD17B1 Products)

Synonyms: EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, SDR28C1 antibody, 17HSDB1 antibody, 17beta-HSD antibody, E2DH antibody, Hsd17ba antibody, 17BHD1 antibody, zfHSD17B1 antibody, hydroxysteroid 17-beta dehydrogenase 1 antibody, hydroxysteroid (17-beta) dehydrogenase 1 antibody, HSD17B1 antibody, Hsd17b1 antibody, hsd17b1 antibody

Background: HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.
Alias Symbols: EDH17B2, EDHB17, HSD17, SDR28C1
Protein Interaction Partner: HSD17B1,
Protein Size: 328

Molecular Weight: 36 kDa

Gene ID: 3292

NCBI Accession: NM_000413, NP_000404

UniProt: P14061

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis