HSD17B1 antibody (N-Term)

Catalog No. ABIN2776958

Cited in 1 publication. The Rabbit Polyclonal anti-HSD17B1 antibody (ABIN2776958) specifically detects HSD17B1 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Horse, Pig, Guinea Pig and Rabbit samples.

Quick Overview for HSD17B1 antibody (N-Term) (ABIN2776958)

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Pig, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HSD17B1 Antibody

Binding Specificity: N-Term

Purpose: HSD17B1 Antibody - N-terminal region

Sequence: MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 91%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HSD17B1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HSD17B1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8102873

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-HSD17B1 antibody (ABIN2776958)

Tsuchiya, Nakao, Katoh, Sasaki, Hiroshima, Tanaka, Matsunaga, Hanaoka, Tsugane, Ikenoue: "Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19." in: Human reproduction (Oxford, England), Vol. 20, Issue 4, pp. 974-8, (2005) (PubMed).

Target Details for HSD17B1

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Alternative Name: HSD17B1

Background:

Background Information: HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.

Gene Name: Hydroxysteroid (17-beta) dehydrogenase 1

Alternative Symbols: E2DH, HSD17, EDHB17, EDH17B2, SDR28C1, 17-beta-HSD, 20-alpha-HSD

Protein Name: Estradiol 17-beta-dehydrogenase 1

Molecular Weight: 36kDa

Gene ID: 3292

NCBI Accession: NP_000404

UniProt: P14061

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis