Growth Hormone 1 antibody (C-Term)

Catalog No. ABIN2776980

The Rabbit Polyclonal anti-Growth Hormone 1 antibody is suitable to detect Growth Hormone 1 in samples from Human, Mouse, Rat, Pig, Cow, Horse, Sheep, Goat and Rabbit. It has been validated for WB.

Quick Overview for Growth Hormone 1 antibody (C-Term) (ABIN2776980)

Target: Growth Hormone 1 (GH1)

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, Goat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Growth Hormone 1 Antibody

Binding Specificity: C-Term

Purpose: GH1 Antibody - C-terminal region

Sequence: TYSKFDTNSH NDDALLKNYG LLYCFRKDMD KVETFLRIVQ CRSVEGSCGF

Predicted Reactivity: Cow: 100%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against GH1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41763-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Growth Hormone 1

Target: Growth Hormone 1 (GH1)

Alternative Name: GH1

Background:

Background Information: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Gene Name: Growth hormone 1

Alternative Symbols: GH, GHN, GH-N, GHB5, IGHD2, hGH-N, IGHD1A, IGHD1B

Protein Name: Growth hormone 1 Ensembl ENSP00000343791

Molecular Weight: 25 kDa

Gene ID: 2688

NCBI Accession: NP_072054

UniProt: A6NEF6

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process