PTGS1 antibody (N-Term)

Catalog No. ABIN2777018

The Rabbit Polyclonal anti-PTGS1 antibody (ABIN2777018) specifically detects PTGS1 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Sheep, Cow, Horse, Dog and Guinea Pig samples.

Quick Overview for PTGS1 antibody (N-Term) (ABIN2777018)

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Reactivity: Human, Mouse, Rat, Sheep, Cow, Horse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PTGS1 Antibody

Binding Specificity: N-Term

Sequence: LDRYQCDCTR TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 93%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against PTGS1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTGS1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 599 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTGS1

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Alternative Name: PTGS1

Background: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis.Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
Alias Symbols: COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Protein Interaction Partner: FBXO6, PTGS2, NCL, CAV2, CAV1, PTGIS, Dlg4, PTGS1, NUCB1,
Protein Size: 599

Molecular Weight: 69 kDa

Gene ID: 5742

NCBI Accession: NM_000962, NP_000953

UniProt: P23219