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CXCR2 antibody (Chemokine (C-X-C Motif) Receptor 2) (N-Term) Primary Antibody

CXCR2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777085
$389.00
Plus shipping costs $45.00
100 μL
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  • Target
    CXCR2
    Binding Specificity
    • 15
    • 15
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 72
    • 47
    • 23
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 66
    • 10
    • 7
    • 1
    Rabbit
    Clonality
    • 75
    • 9
    Polyclonal
    Conjugate
    • 44
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CXCR2 antibody is un-conjugated
    Application
    • 45
    • 34
    • 23
    • 15
    • 15
    • 14
    • 13
    • 13
    • 12
    • 12
    • 6
    • 5
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Sequence
    MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
    Predicted Reactivity
    Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against IL8RB. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human IL8RB
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 360 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CXCR2
    Alternative Name
    IL8RB (CXCR2 Antibody Abstract)
    Synonyms
    CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, CXC-R2, CXCR-2, CD128, CDw128, Cmkar2, Gpcr16, IL-8Rh, IL-8rb, Il8rb, mIL-8RH, C-X-C motif chemokine receptor 2, chemokine (C-X-C motif) receptor 2, Cxcr2, CXCR2
    Background
    IL8RB is the receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. IL8RB binds to IL-8 with high affinity. IL8RB also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CD182, CDw128b, CMKAR2, CXCR2, IL8R2, IL8RA, IL8RB
    Protein Interaction Partner: ST13, RAB11FIP2, CXCL5, PPP2CA, MYO5B, PPBP, GNA14, RGS12, GPRASP1, CXCL1, CXCL8, CXCR1, CXCR2, GNAI3, GNAI2, GNA15, CXCL3, CXCL2, CXCL6, GRIA1, ARRB1, ADRA1A, GTF3A,
    Protein Size: 360
    Molecular Weight
    41 kDa
    Gene ID
    3579
    NCBI Accession
    NM_001557, NP_001548
    UniProt
    P25025
    Pathways
    cAMP Metabolic Process
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