SERPINB5 antibody (Middle Region)

Catalog No. ABIN2777125

This anti-SERPINB5 antibody is a Rabbit Polyclonal antibody detecting SERPINB5 in WB and IHC. Suitable for Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Dog and Horse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for SERPINB5 antibody (Middle Region) (ABIN2777125)

Target: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SERPINB5 Antibody

Binding Specificity: Middle Region

Sequence: NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 93%, Mouse: 86%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SERPINB5. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SERPINB5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 375 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SERPINB5 antibody (ABIN2777125)

Mardin, Ntalos, Mees, Spieker, Senninger, Haier, Dhayat: "SERPINB5 Promoter Hypomethylation Differentiates Pancreatic Ductal Adenocarcinoma From Pancreatitis." in: Pancreas, Vol. 45, Issue 5, pp. 743-7, (2016) (PubMed).

Hrabakova, Kollareddy, Tyleckova, Halada, Hajduch, Gadher, Kovarova: "Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy." in: Journal of proteome research, Vol. 12, Issue 1, pp. 455-69, (2013) (PubMed).

Mardin, Petrov, Enns, Senninger, Haier, Mees: "SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma." in: BMC cancer, Vol. 10, pp. 549, (2010) (PubMed).

Target Details for SERPINB5

Target: SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))

Alternative Name: SERPINB5

Background: As a tumor suppressor, it blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Alias Symbols: PI5, maspin
Protein Interaction Partner: SUMO2, WWOX, FBXO32, KHDRBS3, ISG15, UBC, Cdk1, UCHL5, HDAC1,
Protein Size: 375

Molecular Weight: 41 kDa

Gene ID: 5268

NCBI Accession: NM_002639, NP_002630

UniProt: P36952

Pathways: p53 Signaling