KLF8 antibody (N-Term)

Catalog No. ABIN2777342

Cited in 4+ publications. The Rabbit Polyclonal anti-KLF8 antibody (ABIN2777342) specifically detects KLF8 in WB and IHC. The antibody is reactive with Human, Rabbit, Dog, Horse and Cow samples.

Quick Overview for KLF8 antibody (N-Term) (ABIN2777342)

Target: KLF8 (Kruppel-Like Factor 8 (KLF8))

Reactivity: Human, Rabbit, Dog, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KLF8 Antibody

Binding Specificity: N-Term

Purpose: KLF8 Antibody - N-terminal region

Sequence: LSFHKPKAPL QPASMLQAPI RPPKPQSSPQ TLVVSTSTSD MSTSANIPTV

Predicted Reactivity: Cow: 79%, Dog: 79%, Horse: 77%, Human: 100%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against KLF8. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KLF8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31533-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-KLF8 antibody (ABIN2777342)

Yan, Zhang, Wu, Wu, Zhang, Shi, Zhao, Nan, Chen, Wang, Cheng, Li, Bai, Liu, Wang: "KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2." in: Oncotarget, Vol. 6, Issue 28, pp. 25402-17, (2015) (PubMed).

Han, Han, Sun, Zan, Zhou, Xu, Yao, Liu: "Krüppel?like factor expression and correlation with FAK, MMP?9 and E?cadherin expression in hepatocellular carcinoma." in: Molecular medicine reports, Vol. 8, Issue 1, pp. 81-8, (2013) (PubMed).

Fu, Li, Wu, Yang, Mo, Huang, Xia, Ding, Liu, Zhu: "Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 8, pp. 1255-65, (2010) (PubMed).

Li, Yang, Sun, Xu, Zhou, Qiu, Ke, Cui, Wang, Wang, Liu, Fan: "Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma." in: Gastroenterology, Vol. 139, Issue 6, pp. 2146-2157.e12, (2010) (PubMed).

Target Details for KLF8

Target: KLF8 (Kruppel-Like Factor 8 (KLF8))

Alternative Name: KLF8

Background:

Background Information: KLF8 is abnormally expressed in female patients with X autosome translocation t(X,21)(p11.2,q22.3) and non-syndromic mental retardation.

Gene Name: Kruppel-like factor 8

Alternative Symbols: BKLF3, ZNF741

Protein Name: Krueppel-like factor 8

Molecular Weight: 39kDa

Gene ID: 11279

NCBI Accession: NP_009181

UniProt: O95600