SLC26A3 antibody (Middle Region)

Catalog No. ABIN2777377

This Rabbit Polyclonal antibody specifically detects SLC26A3 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit and Sheep.It has been mentioned in 1 publication

Quick Overview for SLC26A3 antibody (Middle Region) (ABIN2777377)

Target: SLC26A3 (Solute Carrier Family 26, Member 3 (SLC26A3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC26A3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SLC26A3 Antibody

Binding Specificity: Middle Region

Purpose: SLC26A3 Antibody - middle region

Sequence: DAVLHILMKK DYSTSKFNPS QEKDGKIDFT INTNGGLRNR VYEVPVETKF

Predicted Reactivity: Cow: 100%, Dog: 79%, Guinea Pig: 79%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 93%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against SLC26A3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SLC26A3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8112227

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-SLC26A3 antibody (ABIN2777377)

Kjærgaard, Damm, Chang, Riis, Rasmussen, Hytting-Andreasen, Krug, Schulzke, Bindslev, Hansen: "Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?" in: International journal of molecular sciences, Vol. 21, Issue 5, (2020) (PubMed).

Target Details for SLC26A3

Target: SLC26A3 (Solute Carrier Family 26, Member 3 (SLC26A3))

Alternative Name: SLC26A3

Background:

Background Information: SLC26A3 is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.The protein encoded by this gene is a transmembrane glycoprotein that functions as a sulfate transporter. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. Mutations in this gene have been associated with congenital chloride diarrhea. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Solute carrier family 26, member 3

Alternative Symbols: CLD, DRA

Protein Name: Chloride anion exchanger

Molecular Weight: 84 kDa

Gene ID: 1811

NCBI Accession: NP_000102

UniProt: P40879