HOXD3 antibody (Middle Region)

Catalog No. ABIN2777522

There are 2+ publications for this product available. The Rabbit Polyclonal anti-HOXD3 antibody is suitable to detect HOXD3 in samples from Human, Mouse, Rat, Dog, Cow, Horse, Rabbit and Guinea Pig. It has been validated for WB.

Quick Overview for HOXD3 antibody (Middle Region) (ABIN2777522)

Target: HOXD3 (Homeobox D3 (HOXD3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HOXD3 Antibody

Binding Specificity: Middle Region

Purpose: HOXD3 Antibody - middle region

Sequence: AHKGAELNGS CMRPGTGNSQ GGGGGSQPPG LNSEQQPPQP PPPPPTLPPS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HOXD3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HOXD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31964-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-HOXD3 antibody (ABIN2777522)

Kodama, Sakai, Murakami, Murai, Mori, Maruo, Yanai, Masegi: "Immunohistochemical demonstration of angiogenesis-associated homeobox proteins in canine vascular tumours." in: Journal of comparative pathology, Vol. 141, Issue 2-3, pp. 199-203, (2009) (PubMed).

Kodama, Sakai, Matsuura, Murakami, Murai, Mori, Maruo, Kimura, Masegi, Yanai: "Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes." in: BMC cancer, Vol. 9, pp. 363, (2009) (PubMed).

Target Details for HOXD3

Target: HOXD3 (Homeobox D3 (HOXD3))

Alternative Name: HOXD3

Background:

Background Information: HOXD3 (homeobox D3) belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that remove the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. HOXD3 may play a role in the regulation of cell adhesion processes.

Gene Name: Homeobox D3

Alternative Symbols: HOX4, HOX1D, HOX4A, Hox-4.1

Protein Name: Homeobox protein Hox-D3

Molecular Weight: 46kDa

Gene ID: 3232

NCBI Accession: NP_008829

UniProt: P31249