HES1 antibody (C-Term)

Catalog No. ABIN2777527

This anti-HES1 antibody is a Rabbit Polyclonal antibody detecting HES1 in WB. Suitable for Human, Mouse, Rat, Cow, Rabbit, Guinea Pig and Pig.

Quick Overview for HES1 antibody (C-Term) (ABIN2777527)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HES1 Antibody

Binding Specificity: C-Term

Sequence: AFLIPNGAFA HSGPVIPVYT SNSGTSVGPN AVSPSSGSSL TADSMWRPWR

Predicted Reactivity: Cow: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Hes1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Rat

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 281 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Alternative Name: Hes1

Background: Hes1 is the transcriptional repressor of genes that require a bHLH protein for their transcription. Hes1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.
Alias Symbols: Hes1
Protein Interaction Partner: Polr2a, Kat2b, Sfpq, Src, Crebbp, Parp1, Camk2a,
Protein Size: 281

Molecular Weight: 30 kDa

Gene ID: 29577

NCBI Accession: NM_024360, NP_077336

UniProt: Q04666

Pathways: DNA Damage Repair