PAWR antibody (PRKC, Apoptosis, WT1, Regulator) (Middle Region)

Details for Product anti-PAWR Antibody No. ABIN2777555
Antigen
  • MGC81382
  • pawrl
  • zgc:103513
  • PAWR
  • PAR4
  • Par-4
  • Par4
  • 2310001G03Rik
  • pro-apoptotic WT1 regulator
  • PRKC, apoptosis, WT1, regulator L homeolog
  • PRKC, apoptosis, WT1, regulator
  • PAWR
  • pawr.L
  • pawr
  • Pawr
Epitope
Middle Region
5
2
2
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
88
45
45
6
3
3
2
2
2
2
2
Host
Rabbit
82
5
1
Clonality
Polyclonal
Conjugate
This PAWR antibody is un-conjugated
3
3
3
3
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
71
43
38
13
4
3
3
3
3
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human PAWR
Sequence SYLLQEPPRT VSGRYKSTTS VSEEDVSSRY SRTDRSGFPR YNRDANVSGT
Predicted Reactivity Dog: 100%, Horse: 85%, Human: 100%, Mouse: 91%, Rabbit: 77%, Rat: 91%
Characteristics This is a rabbit polyclonal antibody against PAWR. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Plasmids, Primers & others Plasmids, Primers & others PAWR products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PAWR (PAWR Antibody Abstract)
Background The tumor suppressor WT1 represses and activates transcription. Anti-Prostate Apoptosis Response Protein Par-4 (PAWR) is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.
Alias Symbols: PAR4, Par-4
Protein Interaction Partner: FBXO45, UBC, EED, FAM129B, SNX6, CAND1, VPS29, JMJD6, STAT1, SNX2, SHMT2, SHMT1, PPM1G, IDE, H3F3A, CARS, ATP6V1C1, APEH, PAN2, DRD2, DAPK3, SQSTM1, PRKCZ, Spsb4, Spsb2, SPSB1, FBXO25, HSPA5, Cep350, Kif23, THAP1, SLC5A7, AATF, TFPT, PAWR, WT1, RRAS2, ATP
Protein Size: 340
Molecular Weight 37 kDa
Gene ID 5074
NCBI Accession NM_002583, NP_002574
UniProt O75796
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 340 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Image no. 1 for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (Middle Region) antibody (ABIN2777555) WB Suggested Anti-PAWR Antibody Titration: 0.5-1.0ug/ml Positive Control: Jurkat c...
Image no. 2 for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (Middle Region) antibody (ABIN2777555) Human kidney
Image no. 3 for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) (Middle Region) antibody (ABIN2777555) Human Liver
Background publications Bergmann, Kukoc-Zivojnov, Chow, Trepohl, Hoelzer, Weidmann, Mitrou, Boehrer: "Prostate apoptosis response gene-4 sensitizes neoplastic lymphocytes to CD95-induced apoptosis." in: Annals of hematology, Vol. 83, Issue 10, pp. 646-53, 2004 (PubMed).

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