PAWR antibody (Middle Region)

Catalog No. ABIN2777555

Product Details anti-PAWR Antibody

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAWR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SYLLQEPPRT VSGRYKSTTS VSEEDVSSRY SRTDRSGFPR YNRDANVSGT

Predicted Reactivity: Dog: 100%, Horse: 85%, Human: 100%, Mouse: 91%, Rabbit: 77%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against PAWR. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PAWR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 340 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Alternative Name: PAWR (PAWR Products)

Synonyms: MGC81382 antibody, pawrl antibody, zgc:103513 antibody, PAWR antibody, PAR4 antibody, Par-4 antibody, Par4 antibody, 2310001G03Rik antibody, pro-apoptotic WT1 regulator antibody, PRKC, apoptosis, WT1, regulator L homeolog antibody, PRKC, apoptosis, WT1, regulator antibody, PAWR antibody, pawr.L antibody, pawr antibody, Pawr antibody

Background: The tumor suppressor WT1 represses and activates transcription. Anti-Prostate Apoptosis Response Protein Par-4 (PAWR) is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.
Alias Symbols: PAR4, Par-4
Protein Interaction Partner: FBXO45, UBC, EED, FAM129B, SNX6, CAND1, VPS29, JMJD6, STAT1, SNX2, SHMT2, SHMT1, PPM1G, IDE, H3F3A, CARS, ATP6V1C1, APEH, PAN2, DRD2, DAPK3, SQSTM1, PRKCZ, Spsb4, Spsb2, SPSB1, FBXO25, HSPA5, Cep350, Kif23, THAP1, SLC5A7, AATF, TFPT, PAWR, WT1, RRAS2, ATP
Protein Size: 340

Molecular Weight: 37 kDa

Gene ID: 5074

NCBI Accession: NM_002583, NP_002574

UniProt: O75796