Aprataxin antibody (N-Term)

Catalog No. ABIN2777649

The Rabbit Polyclonal anti-Aprataxin antibody (ABIN2777649) specifically detects Aprataxin in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Guinea Pig, Dog, Horse and Rabbit samples.

Quick Overview for Aprataxin antibody (N-Term) (ABIN2777649)

Target: Aprataxin (APTX)

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aprataxin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Aprataxin Antibody

Binding Specificity: N-Term

Purpose: APTX Antibody - N-terminal region

Sequence: MMRVCWLVRQ DSRHQRIRLP HLEAVVIGRG PETKITDKKC SRQQVQLKAE

Predicted Reactivity: Dog: 85%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human APTX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8094861

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Aprataxin

Target: Aprataxin (APTX)

Alternative Name: APTX

Background:

Background Information: APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. APTX may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.

Gene Name: Aprataxin

Alternative Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT

Protein Name: Aprataxin

Molecular Weight: 38kDa

Gene ID: 54840

NCBI Accession: NP_778243

UniProt: Q6JV85

Pathways: DNA Damage Repair, Chromatin Binding