HES6 antibody (Middle Region)

Catalog No. ABIN2777652

Product Details anti-HES6 Antibody

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Cow, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LLAGTEVQAK LENAEVLELT VRRVQGALRG RAREREQLQA EASERFAAGY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 75%, Human: 100%, Mouse: 100%, Rabbit: 75%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against Hes6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Hes6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 224 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HES6

Target: HES6 (Hairy and Enhancer of Split 6 (HES6))

Alternative Name: Hes6 (HES6 Products)

Synonyms: YF-30 antibody, her13.2 antibody, AI326893 antibody, bHLHb41 antibody, HES-6 antibody, bHLHc23 antibody, hes family bHLH transcription factor 6 antibody, hairy and enhancer of split 6 antibody, hes6 antibody, Hes6 antibody, HES6 antibody

Background: Hes6 does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Hes6 also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. It promotes cell differentiation.
Alias Symbols: AI326893, bHLHb41
Protein Interaction Partner: Tle1, Tef, Mycn, Ssbp3, Hes1,
Protein Size: 224

Molecular Weight: 24 kDa

Gene ID: 55927

NCBI Accession: NM_019479, NP_062352

UniProt: Q9JHE6