Endoglin antibody (N-Term)

Catalog No. ABIN2777735

This Rabbit Polyclonal antibody specifically detects Endoglin in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat and Guinea Pig.

Quick Overview for Endoglin antibody (N-Term) (ABIN2777735)

Target: Endoglin (ENG)

Reactivity: Human, Mouse, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Endoglin Antibody

Binding Specificity: N-Term

Sequence: ILEVHVLFLE FPTGPSQLEL TLQASKQNGT WPREVLLVLS VNSSVFLHLQ

Predicted Reactivity: Guinea Pig: 91%, Human: 100%, Mouse: 91%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against ENG. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ENG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 625 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: ENG

Background: Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex since it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia.
Alias Symbols: END, ORW, HHT1, ORW1, CD105
Protein Interaction Partner: ENG, TGFBR2, TGFBR1, TGFB3, TGFB1, ACVRL1, TUFM, TCTEX1D4, TGFBR3, TGFB2, INHBA, BMP7, BMP2, ACVR2A, ACVR1, ACVR2B,
Protein Size: 625

Molecular Weight: 68 kDa

Gene ID: 2022

NCBI Accession: NM_000118, NP_000109

UniProt: P17813