PRDM12 antibody (N-Term)

Catalog No. ABIN2777809

This Rabbit Polyclonal antibody specifically detects PRDM12 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Pig, Zebrafish (Danio rerio) and Guinea Pig.

Quick Overview for PRDM12 antibody (N-Term) (ABIN2777809)

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRDM12 Antibody

Binding Specificity: N-Term

Purpose: PRDM12 Antibody - N-terminal region

Sequence: SFLYGRWRNV LGEQLFEDKS HHASPKTAFT AEVLAQSFSG EVQKLSSLVL

Predicted Reactivity: Cow: 100%, Dog: 91%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Pig: 100%, Rat: 92%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against PRDM12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRDM12

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33218-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRDM12

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Alternative Name: PRDM12

Background:

Background Information: PRDM12 belongs to PR-domain family which are involved in human cancers in an unusual yin-yang fashion. Two products are normally produced from a PR-domain family member which differ by the presence or absence of the PR domain, the PR-plus product is disrupted or underexpressed whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, a result of either genetic or epigenetic events, appears to be an important cause of malignancy. PRDM12 may have a potential role in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion.

Gene Name: PR domain containing 12

Alternative Symbols: PFM9, HSAN8

Protein Name: PR domain zinc finger protein 12

Molecular Weight: 40kDa

Gene ID: 59335

NCBI Accession: NP_067632

UniProt: Q9H4Q4