SLUG antibody (Middle Region)

Catalog No. ABIN2777851

This anti-SLUG antibody is a Rabbit Polyclonal antibody detecting SLUG in WB and IHC. Suitable for Human, Mouse, Rat, Cow, Sheep, Dog, Horse, Rabbit, Guinea Pig and Saccharomyces cerevisiae.

Quick Overview for SLUG antibody (Middle Region) (ABIN2777851)

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reactivity: Human, Mouse, Rat, Cow, Sheep, Dog, Horse, Rabbit, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLUG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SLUG Antibody

Binding Specificity: Middle Region

Sequence: SDTSSKDHSG SESPISDEEE RLQSKLSDPH AIEAEKFQCN LCNKTYSTFS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 79%

Characteristics: This is a rabbit polyclonal antibody against SNAI2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SNAI2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 268 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SLUG

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Alternative Name: SNAI2

Background: SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC10182, SLUG, SLUGH1, WS2D, SNAIL2
Protein Interaction Partner: SAT1, TRIM23, PPP2R2D, PPP6R3, STUB1, TJP2, UBC, TP53, PSMD3, PSMD1, PSMC1, PSMA3, PPP2CB, GSK3B, MDM2, APP, KDM1A, HDAC1, CHD4, Sin3a, HDAC2,
Protein Size: 268

Molecular Weight: 30 kDa

Gene ID: 6591

NCBI Accession: NM_003068, NP_003059

UniProt: O43623