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SLUG antibody (AA 12-124)

SNAI2 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7176604
  • Target See all SLUG (SNAI2) Antibodies
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    Binding Specificity
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 12-124
    Reactivity
    • 48
    • 17
    • 13
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 37
    • 11
    Rabbit
    Clonality
    • 38
    • 9
    Polyclonal
    Conjugate
    • 30
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This SLUG antibody is un-conjugated
    Application
    • 26
    • 18
    • 11
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Zinc finger protein SNAI2 protein (12-124AA)
    Isotype
    IgG
    Top Product
    Discover our top product SNAI2 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))
    Alternative Name
    SNAI2 (SNAI2 Products)
    Synonyms
    Slug antibody, Slugh antibody, Snail2 antibody, snail family transcriptional repressor 2 antibody, snail family zinc finger 2 antibody, Snai2 antibody
    Background

    Background: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

    Aliases: MGC10182 antibody, Neural crest transcription factor Slug antibody, Protein snail homolog 2 antibody, Slug (chicken homolog) zinc finger protein antibody, Slug homolog zinc finger protein antibody, Slug zinc finger protein antibody, SLUGH antibody, SLUGH 1 antibody, SLUGH1 antibody, SNAI 2 antibody, Snai2 antibody, SNAI2_HUMAN antibody, Snail 2 antibody, Snail homolog 2 antibody, Snail2 antibody, WS 2D antibody, WS2D antibody, Zinc finger protein SLUG antibody, Zinc finger protein SNAI2 antibody

    UniProt
    O43623
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