TCF7L2 antibody (N-Term)

Catalog No. ABIN2777926

The Rabbit Polyclonal anti-TCF7L2 antibody is suitable to detect TCF7L2 in samples from Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Pig and Guinea Pig. It has been validated for WB.

Quick Overview for TCF7L2 antibody (N-Term) (ABIN2777926)

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF7L2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TCF7L2 Antibody

Binding Specificity: N-Term

Purpose: TCF7L2 Antibody - N-terminal region

Sequence: MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN

Predicted Reactivity: Cow: 100%, Guinea Pig: 79%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against TCF7L2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33413-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TCF7L2

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Alternative Name: TCF7L2

Background:

Background Information: The TCL7L2 is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. suggested that TCL7L2 acts through regulation of proglucagon through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway. The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM]. Sequence Note: This gene (TCF7L2, alias TCF-4) is distinct from TCF4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-202 DA473655.1 1-202 203-251 Y11306.2 3-51 252-1252 AK225809.1 256-1256 1253-1305 Y11306.2 1053-1105 1306-1756 AK225809.1 1310-1760 1757-1811 Y11306.2 1557-1611 1812-2652 AK225809.1 1765-2605

Gene Name: Transcription factor 7-like 2 (T-cell specific, HMG-box)

Alternative Symbols: TCF4, TCF-4

Protein Name: TCF7L2 protein EMBL CAG38811.1

Molecular Weight: 65kDa

Gene ID: 6934

NCBI Accession: NP_110383

UniProt: Q6FHW4

Pathways: WNT Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus