TUB antibody (N-Term)

Catalog No. ABIN2777955

This Rabbit Polyclonal antibody specifically detects TUB in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Horse, Dog, Rabbit and Guinea Pig.

Quick Overview for TUB antibody (N-Term) (ABIN2777955)

Target: TUB (Tubby Homolog (TUB))

Reactivity: Human, Mouse, Rat, Horse, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TUB Antibody

Binding Specificity: N-Term

Sequence: DSLASVQLGA TRPTAPASAK RTKAAATAGG QGGAARKEKK GKHKGTSGPA

Predicted Reactivity: Dog: 92%, Guinea Pig: 85%, Horse: 85%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against TUB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TUB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 561 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TUB

Target: TUB (Tubby Homolog (TUB))

Alternative Name: TUB

Background: TUB functions in signal transduction from heterotrimeric G protein-coupled receptors. It could be involved in the hypothalamic regulation of body weight. This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.
Alias Symbols: rd5
Protein Interaction Partner: UBC, SUV420H2, GNAQ, SRC, ABL1, PLCG1, PIK3R1, LCK, JAK2, IRS1, GRB2,
Protein Size: 561

Molecular Weight: 62 kDa

Gene ID: 7275

NCBI Accession: NM_003320, NP_003311

UniProt: P50607

Pathways: RTK Signaling, Sensory Perception of Sound