Claudin 19 antibody (C-Term)

Catalog No. ABIN2778043

The Rabbit Polyclonal anti-Claudin 19 antibody (ABIN2778043) specifically detects Claudin 19 in WB. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Guinea Pig, Pig, Rabbit and Horse samples.

Quick Overview for Claudin 19 antibody (C-Term) (ABIN2778043)

Target: Claudin 19 (CLDN19)

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 19 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Claudin 19 Antibody

Binding Specificity: C-Term

Purpose: CLDN19 Antibody - C-terminal region

Sequence: AVLGGSFLCC TCPEPERPNS SPQPYRPGPS AAAREPVVKL PASAKGPLGV

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CLDN19. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN19

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33619-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Claudin 19

Target: Claudin 19 (CLDN19)

Alternative Name: CLDN19

Background:

Background Information: CLDN19 belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: Claudin 19

Alternative Symbols: HOMG5

Protein Name: Claudin-19

Molecular Weight: 23kDa

Gene ID: 149461

NCBI Accession: NP_683763

UniProt: Q8N6F1

Pathways: Cell-Cell Junction Organization, Hepatitis C