BMI1 antibody (Middle Region)
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- Target See all BMI1 Antibodies
- BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Rabbit, Dog, Cow, Horse, Guinea Pig, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BMI1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MDIPNTFQID VMYEEEPLKD YYTLMDIAYI YTWRRNGPLP LKYRVRPTCK
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Zebrafish: 77%
- Characteristics
- This is a rabbit polyclonal antibody against Bmi1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product BMI1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 324 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
- Alternative Name
- Bmi1 (BMI1 Products)
- Synonyms
- FLVI2/BMI1 antibody, PCGF4 antibody, RNF51 antibody, AW546694 antibody, Bmi-1 antibody, Pcgf4 antibody, bmi1 antibody, pcgf4 antibody, psc1 antibody, wu:fb17g03 antibody, wu:fd18f06 antibody, BMI-1 antibody, pcgf4b antibody, bmi-1 antibody, bmi1-a antibody, bmi1-b antibody, bmi1b antibody, rnf51 antibody, xbmi-1 antibody, BMI1 proto-oncogene, polycomb ring finger antibody, BMI1 polycomb ring finger oncogene antibody, Bmi1 polycomb ring finger oncogene antibody, bmi1 polycomb ring finger oncogene 1a antibody, bmi1 polycomb ring finger oncogene 1b antibody, BMI1 proto-oncogene, polycomb ring finger L homeolog antibody, BMI1 antibody, LOC100230513 antibody, Bmi1 antibody, bmi1a antibody, bmi1b antibody, bmi1.L antibody
- Background
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Bmi1 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Alias Symbols: AW546694, Bmi-1, Pcgf4
Protein Interaction Partner: Rnf2, Eed, Aurkb, Phc2, RING1, Gata6, Mph1, Cbfb, Runx1, Cdkn2a, HIST2H2AC, Slc11a1, Dnmt3b, Kdm2b, Phc1, Cbx2, Phc3, Dmap1, CBX8, SCMH1, CBX4, SMARCA5, HSPA4,
Protein Size: 324 - Molecular Weight
- 37 kDa
- Gene ID
- 12151
- NCBI Accession
- NM_007552, NP_031578
- UniProt
- P25916
- Pathways
- Cell Division Cycle, Autophagy
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