MLL4 antibody (AA 1060-1140)

Catalog No. ABIN7229698

The Rabbit Polyclonal anti-MLL4 antibody is suitable to detect MLL4 in samples from Human and Mouse. It has been validated for IHC and IF.

Quick Overview for MLL4 antibody (AA 1060-1140) (ABIN7229698)

Target: MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MLL4 Antibody

Binding Specificity: AA 1060-1140

Purpose: Rabbit Anti-MLL4 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MLL4 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MLL4 protein at AA range: 1060-1140

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MLL4

Target: MLL4 (Histone-Lysine N-Methyltransferase MLL4 (MLL4))

Alternative Name: MLL4

Background: Histone-lysine N-methyltransferase 2B , Lysine N-methyltransferase 2B, Myeloid/lymphoid or mixed-lineage leukemia protein 4, Trithorax homolog 2, WW domain-binding protein 7, WBP-7KMT2B (Lysine Methyltransferase 2B) is a Protein Coding gene. Diseases associated with KMT2B include Dystonia 28, Childhood-Onset and Spindle Cell Sarcoma. Among its related pathways are Chromatin organization and Lysine degradation. KMT2B encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. KMT2B is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for KMT2B, however, the full length nature of the shorter transcript is not known.

Molecular Weight: 298kD

Gene ID: 9757

UniProt: Q9UMN6

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Warburg Effect