KCNA5 antibody (N-Term)

Catalog No. ABIN2778214

This Rabbit Polyclonal antibody specifically detects KCNA5 in WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for KCNA5 antibody (N-Term) (ABIN2778214)

Target: KCNA5 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNA5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNA5 Antibody

Binding Specificity: N-Term

Sequence: DPGVRPLPPL PEELPRPRRP PPEDEEEEGD PGLGTVEDQA LGTASLHHQR

Predicted Reactivity: Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against KCNA5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human KCNA5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 613 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KCNA5

Target: KCNA5 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5))

Alternative Name: KCNA5

Background: Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion.
Alias Symbols: ATFB7, HCK1, HK2, HPCN1, KV1.5, MGC117058, MGC117059, PCN1
Protein Interaction Partner: SIRT1, KCNAB2, ERBB2IP, SNTA1, HSP90AA1, TNK2, Rab11a, DCTN2, GNB2L1, KCNAB1, TFRC, SRC, PRKCQ, PRKCB, KCNA5, KCNA4, KCNA3, KCNA2, FYN, FHL1, DYNC1I1, CAV1, ACTN2, UBE2I, SUMO3, RAB5A, RAB4A, DLG4, DLG1, PTPRE,
Protein Size: 613

Molecular Weight: 67 kDa

Gene ID: 3741

NCBI Accession: NM_002234, NP_002225

UniProt: P22460