EXOSC3 antibody (C-Term)

Catalog No. ABIN2778686

Cited in 1 publication. The Rabbit Polyclonal anti-EXOSC3 antibody (ABIN2778686) specifically detects EXOSC3 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Saccharomyces cerevisiae samples.

Quick Overview for EXOSC3 antibody (C-Term) (ABIN2778686)

Target: EXOSC3 (Exosome Component 3 (EXOSC3))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EXOSC3 Antibody

Binding Specificity: C-Term

Purpose: EXOSC3 Antibody - C-terminal region

Sequence: VIGIVTAKSG DIFKVDVGGS EPASLSYLSF EGATKRNRPN VQAISSRL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against EXOSC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EXOSC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40230-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-EXOSC3 antibody (ABIN2778686)

Fan, Huang-Liu, Shen, Ju, Lin, Pai, Huang, Ho, Tsai, Tsai, Huang: "Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E₂ and/or ERα in LPS-treated H9c2 cardiomyoblast cells." in: The Chinese journal of physiology, Vol. 57, Issue 1, pp. 8-18, (2014) (PubMed).

Target Details for EXOSC3

Target: EXOSC3 (Exosome Component 3 (EXOSC3))

Alternative Name: EXOSC3

Background:

Background Information: EXOSC3 is component of the exosome 3'->5' exoribonuclease complex and is required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA.

Gene Name: Exosome component 3

Alternative Symbols: p10, PCH1B, RRP40, Rrp40p, CGI-102, hRrp-40, bA3J10.7

Protein Name: Exosome complex component RRP40

Molecular Weight: 17kDa

Gene ID: 51010

NCBI Accession: NP_001002269

UniProt: Q9NQT5

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome