CPNE1 antibody (Middle Region)

Catalog No. ABIN2778879

The Rabbit Polyclonal anti-CPNE1 antibody is suitable to detect CPNE1 in samples from Human, Mouse, Cow, Dog, Horse, Rabbit, Rat, Sheep, Guinea Pig, Zebrafish (Danio rerio) and Pig. It has been validated for WB.

Quick Overview for CPNE1 antibody (Middle Region) (ABIN2778879)

Target: CPNE1 (Copine I (CPNE1))

Reactivity: Human, Mouse, Cow, Dog, Horse, Rabbit, Rat, Sheep, Guinea Pig, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPNE1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CPNE1 Antibody

Binding Specificity: Middle Region

Purpose: CPNE1 Antibody - middle region

Sequence: VQCSDYDSDG SHDLIGTFHT SLAQLQAVPA EFECIHPEKQ QKKKSYKNSG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 91%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against CPNE1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CPNE1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40503-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CPNE1

Target: CPNE1 (Copine I (CPNE1))

Alternative Name: CPNE1

Background:

Background Information: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. CPNE1 is a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.

Gene Name: Copine I

Alternative Symbols: CPN1, COPN1

Protein Name: Copine-1

Molecular Weight: 59kDa

Gene ID: 8904

NCBI Accession: NP_003906

UniProt: Q99829