EWSR1 antibody (Middle Region)

Catalog No. ABIN2779045

This Rabbit Polyclonal antibody specifically detects EWSR1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig and Rabbit.

Quick Overview for EWSR1 antibody (Middle Region) (ABIN2779045)

Target: EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EWSR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-EWSR1 Antibody

Binding Specificity: Middle Region

Sequence: QPSSYGQQSS YGQQSSYGQQ PPTSYPPQTG SYSQAPSQYS QQSSSYGQQS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against EWSR1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EWSR1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 656 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EWSR1

Target: EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))

Alternative Name: EWSR1

Background: EWSR1 is a putative RNA binding protein. Mutations in this gene, specifically a t(11,22)(q24,q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in two products.This gene encodes a putative RNA binding protein. Mutations in this gene, specifically a t(11,22)(q24,q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in two products.
Alias Symbols: EWS, bK984G1.4
Protein Interaction Partner: SSBP3, SEC24A, TFG, SEC24D, PEF1, MAPK1IP1L, ATPAF2, TRAF2, TRAF1, PLSCR1, PRR13, UBC, RPA3, RPA2, RPA1, EZH2, SUZ12, RNF2, BMI1, rev, ITCH, WBP4, PRMT1, CCDC7, YY1AP1, MRPS18B, UBD, CD81, RIOK2, NONO, ITGB5, ITGA4, FUS, FN1, EWSR1, EPAS1, EP300, HNRNPUL1
Protein Size: 656

Molecular Weight: 68 kDa

Gene ID: 2130

NCBI Accession: NM_005243, NP_005234

UniProt: Q01844