HSD17B11 antibody (Middle Region)

Catalog No. ABIN2779101

This Rabbit Polyclonal antibody specifically detects HSD17B11 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Pig.

Quick Overview for HSD17B11 antibody (Middle Region) (ABIN2779101)

Target: HSD17B11 (Hydroxysteroid (17-Beta) Dehydrogenase 11 (HSD17B11))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HSD17B11 Antibody

Binding Specificity: Middle Region

Purpose: Hsd17b11 Antibody - middle region

Sequence: IYSAAKKVKE EVGDVSILVN NAGVVYTADL FATQDPQIEK TFEVNVLAHF

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Hsd17b11. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40842-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSD17B11

Target: HSD17B11 (Hydroxysteroid (17-Beta) Dehydrogenase 11 (HSD17B11))

Alternative Name: Hsd17b11

Background:

Background Information: Hsd17b11 can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. Hsd17b11 may act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. It has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione.

Gene Name: Hydroxysteroid (17-beta) dehydrogenase 11

Alternative Symbols: Pa, Dhr, SDR2, retS, Dhrs8, Pan1b, retSDR2

Protein Name: Estradiol 17-beta-dehydrogenase 11

Molecular Weight: 33kDa

Gene ID: 114664

NCBI Accession: NP_444492

UniProt: Q9EQ06