BAK1 antibody (N-Term)

Catalog No. ABIN2779335

The Rabbit Polyclonal anti-BAK1 antibody (ABIN2779335) specifically detects BAK1 in WB. The antibody is reactive with Human and Horse samples.

Quick Overview for BAK1 antibody (N-Term) (ABIN2779335)

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAK1 Antibody

Binding Specificity: N-Term

Purpose: BAK1 Antibody - N-terminal region

Sequence: ASGQGPGPPR QECGEPALPS ASEEQVAQDT EEVFRSYVFY RHQQEQEAEG

Predicted Reactivity: Horse: 80%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against BAK1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30473-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BAK1

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Alternative Name: BAK1

Background:

Background Information: BAK1 belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Gene Name: BCL2-antagonist/killer 1

Alternative Symbols: BAK, CDN1, BCL2L7, BAK-LIKE

Protein Name: Bcl-2 homologous antagonist/killer

Molecular Weight: 23kDa

Gene ID: 578

NCBI Accession: NP_001179

UniProt: Q16611

Pathways: Apoptosis, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response