IDE antibody (N-Term)

Catalog No. ABIN2779367

This anti-IDE antibody is a Rabbit Polyclonal antibody detecting IDE in WB. Suitable for Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Guinea Pig, Pig and Zebrafish (Danio rerio).

Quick Overview for IDE antibody (N-Term) (ABIN2779367)

Target: IDE (Insulin-Degrading Enzyme (IDE))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Guinea Pig, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDE antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IDE Antibody

Binding Specificity: N-Term

Sequence: LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against IDE. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1019 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IDE

Target: IDE (Insulin-Degrading Enzyme (IDE))

Alternative Name: IDE

Background: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.
Alias Symbols: FLJ35968, INSULYSIN
Protein Interaction Partner: UBC, DCP2, SUMO1, NEDD8, PUS1, TBC1D15, PUS7, ARFIP1, GSPT2, PRMT3, STAT1, SHMT2, SHMT1, PAWR, GSPT1, CTTN, CARS, ATP6V1C1, PEX5, IFIH1, Cdk1, UCHL5, SIRT4, AR, INS, IGF2, IGF1, NR3C1, APP, ZHX2,
Protein Size: 1019

Molecular Weight: 118 kDa

Gene ID: 3416

NCBI Accession: NM_004969, NP_004960

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome