Serotonin Receptor 2B antibody (N-Term)

Catalog No. ABIN2779377

The Rabbit Polyclonal anti-Serotonin Receptor 2B antibody is suitable to detect Serotonin Receptor 2B in samples from Human, Cow, Dog, Guinea Pig, Pig and Horse. It has been validated for WB and IF.

Quick Overview for Serotonin Receptor 2B antibody (N-Term) (ABIN2779377)

Target: Serotonin Receptor 2B (HTR2B) (5-Hydroxytryptamine (serotonin) Receptor 2B (HTR2B))

Reactivity: Human, Cow, Dog, Guinea Pig, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 2B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Serotonin Receptor 2B Antibody

Binding Specificity: N-Term

Purpose: HTR2B Antibody - N-terminal region

Sequence: QTESIPEEMK QIVEEQGNKL HWAALLILMV IIPTIGGNTL VILAVSLEKK

Predicted Reactivity: Cow: 100%, Dog: 80%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Pig: 87%

Characteristics: This is a rabbit polyclonal antibody against HTR2B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HTR2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30716-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Serotonin Receptor 2B

Target: Serotonin Receptor 2B (HTR2B) (5-Hydroxytryptamine (serotonin) Receptor 2B (HTR2B))

Alternative Name: HTR2B

Background:

Background Information: Multiple receptor subtypes of serotonin neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets, central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens.

Gene Name: 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Alternative Symbols: 5-HT2B, 5-HT-2B, 5-HT(2B)

Protein Name: 5-hydroxytryptamine receptor 2B

Molecular Weight: 54 kDa

Gene ID: 3357

NCBI Accession: NP_000858

UniProt: P41595

Pathways: JAK-STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process