MTF1 antibody (C-Term)

Catalog No. ABIN2779426

The Rabbit Polyclonal anti-MTF1 antibody is suitable to detect MTF1 in samples from Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for MTF1 antibody (C-Term) (ABIN2779426)

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MTF1 Antibody

Binding Specificity: C-Term

Purpose: MTF1 Antibody - C-terminal region

Sequence: QSSLVMGEQN LQWILNGATS SPQNQEQIQQ ASKVEKVFFT TAVPVASSPG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MTF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MTF1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32027-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Alternative Name: MTF1

Background:

Background Information: The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein.

Gene Name: Metal-regulatory transcription factor 1

Alternative Symbols: ZRF, MTF-1

Protein Name: Metal regulatory transcription factor 1

Molecular Weight: 81kDa

Gene ID: 4520

NCBI Accession: NP_005946

UniProt: Q14872