PAX4 antibody (Middle Region)

Catalog No. ABIN2779444

There is 1 publication for this product available. The Rabbit Polyclonal anti-PAX4 antibody is suitable to detect PAX4 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for PAX4 antibody (Middle Region) (ABIN2779444)

Target: PAX4 (Paired Box 4 (PAX4))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAX4 Antibody

Binding Specificity: Middle Region

Purpose: PAX4 Antibody - middle region

Sequence: RTIFSPSQAE ALEKEFQRGQ YPDSVARGKL ATATSLPEDT VRVWFSNRRA

Specificity: 100 % homologous to all 3 isoforms (38, 30, 37 kDa).

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against PAX4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PAX4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8107541

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PAX4 antibody (ABIN2779444)

Zhang, Smyrk, Oliveira, Lohse, Zhang, Johnson, Lloyd: "KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers." in: The American journal of surgical pathology, Vol. 33, Issue 10, pp. 1562-9, (2010) (PubMed).

Target Details for PAX4

Target: PAX4 (Paired Box 4 (PAX4))

Alternative Name: PAX4

Background:

Background Information: PAX4 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing .- cells.

Gene Name: Paired box 4

Alternative Symbols: KPD, MODY9

Protein Name: Paired box gene 4 EMBL EAL24318.1

Molecular Weight: 38 kDa

Gene ID: 5078

NCBI Accession: NP_006184

UniProt: O43316