T-Box 19 antibody (Middle Region)

Catalog No. ABIN2779591

The Rabbit Polyclonal anti-T-Box 19 antibody has been validated for WB. It is suitable to detect T-Box 19 in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit and Pig.

Quick Overview for T-Box 19 antibody (Middle Region) (ABIN2779591)

Target: T-Box 19 (TBX19)

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 19 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-T-Box 19 Antibody

Binding Specificity: Middle Region

Sequence: IKYNPFAKAF LDAKERNHLR DVPEAISESQ HVTYSHLGGW IFSNPDGVCT

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against TBX19. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TBX19

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 448 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for T-Box 19

Target: T-Box 19 (TBX19)

Alternative Name: TBX19

Background: TBX19 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage.This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ26302, FLJ34543, TBS 19, TBS19, TPIT, dJ747L4.1
Protein Interaction Partner: NR5A1,
Protein Size: 448

Molecular Weight: 48 kDa

Gene ID: 9095

NCBI Accession: NM_005149, NP_005140

UniProt: O60806