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T-Box 19 (TBX19) (Middle Region) antibody Primary Antibody

TBX19 Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat WB Host: Rabbit Polyclonal
Catalog No. ABIN2779591
$229.00
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100 μL
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  • Target
    Binding Specificity
    Middle Region
    Reactivity
    Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Western Blotting (WB)
    Blocking Peptide
    Blocking peptide for this product available: ABIN984832
    Sequence
    IKYNPFAKAF LDAKERNHLR DVPEAISESQ HVTYSHLGGW IFSNPDGVCT
    Predicted Reactivity
    Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 77%
    Characteristics
    This is a rabbit polyclonal antibody against TBX19. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human TBX19
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 448 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Alternative Name
    TBX19 (TBX19 Antibody Abstract)
    Background
    TBX19 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage.This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: FLJ26302, FLJ34543, TBS 19, TBS19, TPIT, dJ747L4.1
    Protein Interaction Partner: NR5A1,
    Protein Size: 448
    Molecular Weight
    48 kDa
    Gene ID
    9095
    NCBI Accession
    NM_005149, NP_005140
    UniProt
    O60806
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