T-Box 19 (TBX19) (Middle Region) antibody

Details for Product No. ABIN2779591
Antigen
  • TBX19
  • TBS19
  • TPIT
  • dJ747L4.1
  • CH-TBXT
  • TBXT
  • AU019250
  • D1Ertd754e
  • Tpit
  • T-box 19
  • TBX19
  • Tbx19
Epitope
Middle Region
4
2
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
15
9
5
4
3
2
2
2
2
1
1
1
Host
Rabbit
12
4
Clonality
Polyclonal
Application
Western Blotting (WB)
16
4
3
3
3
2
Options
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human TBX19
Blocking Peptide Blocking peptide for this product available: ABIN984832
Sequence IKYNPFAKAF LDAKERNHLR DVPEAISESQ HVTYSHLGGW IFSNPDGVCT
Predicted Reactivity Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 77%
Characteristics This is a rabbit polyclonal antibody against TBX19. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Antigen
Alternative Name TBX19 (TBX19 Antibody Abstract)
Background TBX19 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage.This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ26302, FLJ34543, TBS 19, TBS19, TPIT, dJ747L4.1
Protein Interaction Partner: NR5A1,
Protein Size: 448
Molecular Weight 48 kDa
Gene ID 9095
NCBI Accession NM_005149, NP_005140
UniProt O60806
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 448 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Image no. 1 for anti-T-Box 19 (TBX19) (Middle Region) antibody (ABIN2779591) WB Suggested Anti-TBX19 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Po...
Background publications Maira, Couture, Le Martelot, Pulichino, Bilodeau, Drouin: "The T-box factor Tpit recruits SRC/p160 co-activators and mediates hormone action." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46523-32, 2003 (PubMed).

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