SIRT2 antibody (C-Term)

Catalog No. ABIN2779606

The Rabbit Polyclonal anti-SIRT2 antibody (ABIN2779606) specifically detects SIRT2 in WB. The antibody is reactive with Human, Rat, Mouse, Rabbit, Guinea Pig, Dog, Cow and Zebrafish (Danio rerio) samples.

Quick Overview for SIRT2 antibody (C-Term) (ABIN2779606)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reactivity: Human, Rat, Mouse, Rabbit, Guinea Pig, Dog, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIRT2 Antibody

Binding Specificity: C-Term

Purpose: SIRT2 Antibody - C-terminal region

Sequence: DVAWLGECDQ GCLALAELLG WKKELEDLVR REHASIDAQS GAGVPNPSTS

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%, Zebrafish: 75%

Characteristics: This is a rabbit polyclonal antibody against SIRT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIRT2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111800

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Alternative Name: SIRT2

Background:

Background Information: SIRT2 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.

Gene Name: Sirtuin 2

Alternative Symbols: SIR2, SIR2L, SIR2L2

Protein Name: NAD-dependent protein deacetylase sirtuin-2

Molecular Weight: 40kDa

Gene ID: 22933

NCBI Accession: NP_085096

UniProt: Q8IXJ6