OTX2 antibody (Middle Region)

Catalog No. ABIN2779644

The Rabbit Polyclonal anti-OTX2 antibody is suitable to detect OTX2 in samples from Human, Rat, Mouse, Zebrafish (Danio rerio), Dog, Sheep, Rabbit, Horse, Cow and Guinea Pig. It has been validated for WB.

Quick Overview for OTX2 antibody (Middle Region) (ABIN2779644)

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reactivity: Human, Rat, Mouse, Zebrafish (Danio rerio), Dog, Sheep, Rabbit, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTX2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OTX2 Antibody

Binding Specificity: Middle Region

Sequence: QQNGGQNKVR PAKKKTSPAR EVSSESGTSG QFTPPSSTSV PTIASSSAPV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against OTX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human OTX2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 297 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Alternative Name: OTX2

Background: Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. This protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
Alias Symbols: MCOPS5, MGC45000, CPHD6
Protein Interaction Partner: ATXN1, CDK4, APP, DMBX1, TLE4, FOXA2, MITF, OTX2, LHX1,
Protein Size: 297

Molecular Weight: 32 kDa

Gene ID: 5015

NCBI Accession: NM_021728, NP_068374

Pathways: Dopaminergic Neurogenesis