Paired Box 3 antibody (N-Term)

Catalog No. ABIN2779648

The Rabbit Polyclonal anti-Paired Box 3 antibody has been validated for WB. It is suitable to detect Paired Box 3 in samples from Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit and Saccharomyces cerevisiae.

Quick Overview for Paired Box 3 antibody (N-Term) (ABIN2779648)

Target: Paired Box 3 (PAX3)

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Paired Box 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Paired Box 3 Antibody

Binding Specificity: N-Term

Sequence: DRNTVPSVSS ISRILRSKFG KGEEEEADLE RKEAEESEKK AKHSIDGILS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against PAX3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PAX3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 484 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Paired Box 3

Target: Paired Box 3 (PAX3)

Alternative Name: PAX3

Background: PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
Alias Symbols: CDHS, HUP2, MGC120381, MGC120382, MGC120383, MGC120384, MGC134778, WS1, WS3
Protein Interaction Partner: PCTP, UBC, TAF1, POU3F2, HDAC1, TRIM28, HDAC10, SOX8, WWTR1, PAX3, DAXX, CIB1, SOX10, MEOX2, MEOX1, MITF, MSX1, Rad23b, PSMD4, TBP, IPO13, CNR1,
Protein Size: 484

Molecular Weight: 53 kDa

Gene ID: 5077

NCBI Accession: NM_181458, NP_852123

UniProt: Q494Z3

Pathways: Sensory Perception of Sound, Tube Formation