NCOR2 antibody (N-Term)

Catalog No. ABIN2779659

This Rabbit Polyclonal antibody specifically detects NCOR2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Pig, Cow and Dog.

Quick Overview for NCOR2 antibody (N-Term) (ABIN2779659)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivity: Human, Mouse, Rat, Pig, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NCOR2 Antibody

Binding Specificity: N-Term

Sequence: DKEDLLKEKT DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA

Predicted Reactivity: Cow: 86%, Dog: 86%, Human: 100%, Mouse: 79%, Pig: 79%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against NCOR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2524 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Alternative Name: NCOR2

Background: NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
Alias Symbols: SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau
Protein Interaction Partner: HDAC4, HDAC3, RARA, HMGA1, HDAC2, HDAC1, AURKA, BCL6, BCOR, GPS2, ZBTB16, UBC, E2F1, NR1I2, BTRC, HDAC7, NR1H2, THRA, RUNX1, Pparg, Nr2f1, Nr1i3, Nr2f2, CBX6, C1D, NR1H4, NR1D1, Ppard, SUMO2, CTBP1, ARNT, AHR, NCOR1, AR, NRD1, E2F4, ZBTB7A, SOX2, ESR1, CE
Protein Size: 2524

Molecular Weight: 275 kDa

Gene ID: 9612

NCBI Accession: NM_006312, NP_006303

UniProt: Q9Y618

Pathways: Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha