KAT2B antibody (N-Term)

Catalog No. ABIN2779660

The Rabbit Polyclonal anti-KAT2B antibody has been validated for WB. It is suitable to detect KAT2B in samples from Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for KAT2B antibody (N-Term) (ABIN2779660)

Target: KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KAT2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KAT2B Antibody

Binding Specificity: N-Term

Sequence: LFKLLRKSIL QRGKPVVEGS LEKKPPFEKP SIEQGVNNFV QYKFSHLPAK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Characteristics: This is a rabbit polyclonal antibody against PCAF. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCAF

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 832 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KAT2B

Target: KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

Alternative Name: PCAF

Background: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Alias Symbols: P, CAF, PCAF, P/CAF
Protein Interaction Partner: MDM2, HNRNPD, ACLY, KLF2, E2F1, VHL, IRF1, TAL1, TAF12, TAF10, TAF9, TADA2A, RB1, HIST1H1B, TAF5L, TAF6L, TADA3, SUPT3H, TWIST1, PDK1, AKT1, UBC, SIAH2, UBE2D3, UBE2D1, TP73, TP53, SRC, PGR, YEATS2, MBIP, WDR5, PTEN, DR1, HIF1A, HIST2H3C, CHEK2, HIST1H4A,
Protein Size: 832

Molecular Weight: 93 kDa

Gene ID: 8850

NCBI Accession: NM_003884, NP_003875

UniProt: Q92831

Pathways: p53 Signaling, Regulation of Carbohydrate Metabolic Process