HIC1 antibody (N-Term)

Catalog No. ABIN2779756

The Rabbit Polyclonal anti-HIC1 antibody is suitable to detect HIC1 in samples from Human, Mouse, Rat and Guinea Pig. It has been validated for WB.

Quick Overview for HIC1 antibody (N-Term) (ABIN2779756)

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reactivity: Human, Mouse, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HIC1 Antibody

Binding Specificity: N-Term

Sequence: ALCASERRCS PLCGLDLSKK SPPGSAAPER PLAERELPPR PDSPPSAGPA

Predicted Reactivity: Guinea Pig: 79%, Human: 100%, Mouse: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against HIon Channel1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HIC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 714 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Alternative Name: HIC1

Background: HIon Channel1 is a transcriptional repressor. HIon Channel1 may act as a tumor suppressor. HIon Channel1 may be involved in development of head, face, limbs and ventral body wall. Defects in HIon Channel1 may be a cause of the facial dysmorphism and additional birth defects (except for lissencephaly) seen in the contiguous gene disorder Miller-Dieker syndrome (MDS), like defective development of the nose, jaws, extremities, gastrointestinal tract, and kidney.
Alias Symbols: hic-1, ZBTB29, ZNF901
Protein Interaction Partner: PIAS4, PIAS3, PIAS2, SP1, STAT3, SIRT1, MTA1, UBE2I, SUMO2, HIC2, TCF4, CTBP2, CTBP1, EED, PHF1, EZH2, PHF19, SUZ12, UBC, MBD3, RBBP4, CHD3, SENP3, HDAC4, PIAS1, ARID1A, HIC1, HDAC1,
Protein Size: 714

Molecular Weight: 74 kDa

Gene ID: 3090

NCBI Accession: NM_006497, NP_006488

Pathways: Positive Regulation of Response to DNA Damage Stimulus