IRF1 antibody (Middle Region)

Catalog No. ABIN2779861

This Rabbit Polyclonal antibody specifically detects IRF1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Sheep, Horse and Saccharomyces cerevisiae.

Quick Overview for IRF1 antibody (Middle Region) (ABIN2779861)

Target: IRF1 (Interferon Regulatory Factor 1 (IRF1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Sheep, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF1 Antibody

Binding Specificity: Middle Region

Sequence: DIIPDSTTDL YNLQVSPMPS TSEAATDEDE EGKIAEDLMK LFEQSEWQPT

Predicted Reactivity: Cow: 85%, Dog: 83%, Guinea Pig: 92%, Horse: 83%, Human: 83%, Mouse: 100%, Rabbit: 85%, Rat: 92%, Sheep: 85%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against Irf1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 329 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IRF1

Target: IRF1 (Interferon Regulatory Factor 1 (IRF1))

Alternative Name: Irf1

Background: Irf1 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes.Irf1 acts as a tumor suppressor.
Alias Symbols: AU020929, Irf-1
Protein Interaction Partner: Ubc, Sumo1, Ube2i, Pias3, Tbk1, Polr2a,
Protein Size: 329

Molecular Weight: 37 kDa

Gene ID: 16362

NCBI Accession: NM_008390, NP_032416

UniProt: P15314

Pathways: Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagy