TFAM antibody (C-Term)

Catalog No. ABIN2779903

The Rabbit Polyclonal anti-TFAM antibody (ABIN2779903) specifically detects TFAM in WB and IHC. The antibody is reactive with Mouse, Rat, Cow and Rabbit samples.

Quick Overview for TFAM antibody (C-Term) (ABIN2779903)

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivity: Mouse, Rat, Cow, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TFAM Antibody

Binding Specificity: C-Term

Purpose: Tfam Antibody - C-terminal region

Sequence: FQEAKDDSAQ GKLKLVNEAW KNLSPEEKQA YIQLAKDDRI RYDNEMKSWE

Predicted Reactivity: Cow: 79%, Mouse: 100%, Rabbit: 79%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Tfam. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of mouse Tfam

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36993-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Alternative Name: Tfam

Background:

Background Information: TFAM a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this protein is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns Sayre syndrome was produced when expression of the gene was eliminated by targeted disruption in heart and muscle cells.

Gene Name: Transcription factor A, mitochondrial

Alternative Symbols: Hmgt, mtTF, tsHM, Hmgts, mtTFA, tsHMG, AI661103

Protein Name: Transcription factor A, mitochondrial

Molecular Weight: 29 kDa

Gene ID: 21780

NCBI Accession: NP_033386

UniProt: P40630

Pathways: Chromatin Binding