PDX1 antibody (N-Term)

Catalog No. ABIN2780330

The Rabbit Polyclonal anti-PDX1 antibody has been validated for WB. It is suitable to detect PDX1 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Pig.

Quick Overview for PDX1 antibody (N-Term) (ABIN2780330)

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDX1 Antibody

Binding Specificity: N-Term

Sequence: MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF

Predicted Reactivity: Cow: 100%, Dog: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PDX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 283 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Alternative Name: PDX1

Background: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of
Alias Symbols: IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1, GSF
Protein Interaction Partner: UBC, MAPK14, PCIF1, Dlg4, ATF3, PBX1, XRCC5, PRKDC, XRCC6, ALK, SPOP, MAFA, NEUROD1, PDX1, IAPP, TCF3, SLC2A2, CREB1,
Protein Size: 283

Molecular Weight: 31 kDa

Gene ID: 3651

NCBI Accession: NM_000209, NP_000200

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location