MEFV antibody (N-Term)

Catalog No. ABIN2780331

The Rabbit Polyclonal anti-MEFV antibody (ABIN2780331) specifically detects MEFV in WB. The antibody is reactive with Human, Horse, Rabbit and Pig samples.

Quick Overview for MEFV antibody (N-Term) (ABIN2780331)

Target: MEFV (Mediterranean Fever (MEFV))

Reactivity: Human, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEFV antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MEFV Antibody

Binding Specificity: N-Term

Purpose: MEFV Antibody - N-terminal region

Sequence: MAKTPSDHLL STLEELVPYD FEKFKFKLQN TSVQKEHSRI PRSQIQRARP

Predicted Reactivity: Horse: 85%, Human: 100%, Pig: 77%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against MEFV. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MEFV

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37973-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MEFV

Target: MEFV (Mediterranean Fever (MEFV))

Alternative Name: MEFV

Background:

Background Information: MEFV was identified as the gene that when mutated causes Mediterranean fever, a hereditary periodic fever syndrome. MEFV is expressed in granulocytes and myeloid bone marrow precursors. This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Mediterranean fever

Alternative Symbols: FMF, MEF, PAAND, TRIM20

Protein Name: Pyrin

Molecular Weight: 86kDa

Gene ID: 4210

NCBI Accession: NP_000234

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity