HMGA1 antibody (N-Term)

Catalog No. ABIN2780401

The Rabbit Polyclonal anti-HMGA1 antibody has been validated for WB. It is suitable to detect HMGA1 in samples from Human, Rat, Mouse, Dog, Cow, Rabbit, Horse, Guinea Pig, Zebrafish (Danio rerio), Goat and Saccharomyces cerevisiae.

Quick Overview for HMGA1 antibody (N-Term) (ABIN2780401)

Target: HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))

Reactivity: Human, Rat, Mouse, Dog, Cow, Rabbit, Horse, Guinea Pig, Zebrafish (Danio rerio), Goat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HMGA1 Antibody

Binding Specificity: N-Term

Sequence: MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPKEPSEV PTPKRPRGRP

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against HMGA1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HMGA1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 96 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HMGA1

Target: HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))

Alternative Name: HMGA1

Background: This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: HMG-R, HMGA1A, HMGIY, MGC12816, MGC4242, MGC4854
Protein Interaction Partner: NCOR2, UBE2I, PPARG, UBC, UPF2, HTT, OLA1, DNAJC8, PSIP1, METAP2, SYNCRIP, CWC27, HNRNPDL, EIF2S2, PCBP2, PCBP1, PA2G4, NPM1, NCL, HSPA1A, HNRNPL, HNRNPD, HNRNPAB, HNRNPA1, HMGB3, HMGB2, HMGB1, GTF2F2, XRCC6, CSNK2A1, RCC1, CDK1, APEX1, ANXA2, ANXA1, SSB,
Protein Size: 96

Molecular Weight: 11 kDa

Gene ID: 3159

NCBI Accession: NM_002131, NP_002122

UniProt: Q5T6U8

Pathways: Nuclear Hormone Receptor Binding, Autophagy